Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C

We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated kinase (MAPK) and p53 activation and rescuing cell death in isolated adult cardiomyocytes. The pattern of activation and the role of oxidative s...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Ludke, Ana, Akolkar, Gauri, Ayyappan, Prathapan, Sharma, Anita K., Singal, Pawan K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497966/
https://ncbi.nlm.nih.gov/pubmed/28678856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179452
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