Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

BACKGROUND: Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS productio...

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Veröffentlicht in:PLoS Med
Hauptverfasser: Dyson, Alex, Dal-Pizzol, Felipe, Sabbatini, Giovanni, Lach, Anna B., Galfo, Federica, dos Santos Cardoso, Juliano, Pescador Mendonça, Bruna, Hargreaves, Iain, Bollen Pinto, Bernardo, Bromage, Daniel I., Martin, John F., Moore, Kevin P., Feelisch, Martin, Singer, Mervyn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497958/
https://ncbi.nlm.nih.gov/pubmed/28678794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002310
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