Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

BACKGROUND: Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS productio...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Dyson, Alex, Dal-Pizzol, Felipe, Sabbatini, Giovanni, Lach, Anna B., Galfo, Federica, dos Santos Cardoso, Juliano, Pescador Mendonça, Bruna, Hargreaves, Iain, Bollen Pinto, Bernardo, Bromage, Daniel I., Martin, John F., Moore, Kevin P., Feelisch, Martin, Singer, Mervyn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497958/
https://ncbi.nlm.nih.gov/pubmed/28678794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002310
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