Diabetes-induced oxidative stress mediates upregulation of RhoA/Rho kinase pathway and hypercontractility of gastric smooth muscle

The pathogenesis of diabetes-associated motility disorders are multifactorial and attributed to abnormalities in extrinsic and intrinsic innervation, and a decrease in the number of interstitial cells of Cajal, and nNOS expression and activity. Here we studied the effect of hyperglycemia on smooth m...

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Veröffentlicht in:PLoS One
Hauptverfasser: Mahavadi, Sunila, Sriwai, Wimolpak, Manion, Olivia, Grider, John R., Murthy, Karnam S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497948/
https://ncbi.nlm.nih.gov/pubmed/28678840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178574
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