O(2)(•−) and H(2)O(2)-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H(2)O(2); however, the mechanism(s) f...

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Publicat a:Cancer Cell
Autors principals: Schoenfeld, Joshua D., Sibenaller, Zita A., Mapuskar, Kranti A., Wagner, Brett A., Cramer-Morales, Kimberly L., Furqan, Muhammad, Sandhu, Sonia, Carlisle, Thomas L., Smith, Mark C., Hejleh, Taher Abu, Berg, Daniel J., Zhang, Jun, Keech, John, Parekh, Kalpaj R., Bhatia, Sudershan, Monga, Varun, Bodeker, Kellie L., Ahmann, Logan, Vollstedt, Sandy, Brown, Heather, Shanahan Kauffman, Erin P., Schall, Mary E., Hohl, Ray J., Clamon, Gerald H., Greenlee, Jeremy D., Howard, Matthew A., Shultz, Michael K., Smith, Brian J., Riley, Dennis P., Domann, Frederick E., Cullen, Joseph J., Buettner, Garry R., Buatti, John M., Spitz, Douglas R., Allen, Bryan G.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497844/
https://ncbi.nlm.nih.gov/pubmed/28366679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.02.018
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