De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity

In nature, structural specificity in DNA and proteins is encoded quite differently: in DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar inter...

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Foilsithe in:Science
Main Authors: Boyken, Scott E., Chen, Zibo, Groves, Benjamin, Langan, Robert A., Oberdorfer, Gustav, Ford, Alex, Gilmore, Jason, Xu, Chunfu, DiMaio, Frank, Pereira, Jose Henrique, Sankaran, Banumathi, Seelig, Georg, Zwart, Peter H., Baker, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497568/
https://ncbi.nlm.nih.gov/pubmed/27151862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8865
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