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De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity
In nature, structural specificity in DNA and proteins is encoded quite differently: in DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar inter...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5497568/ https://ncbi.nlm.nih.gov/pubmed/27151862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8865 |
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