De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity

In nature, structural specificity in DNA and proteins is encoded quite differently: in DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing complemented by irregular peripheral polar inter...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Boyken, Scott E., Chen, Zibo, Groves, Benjamin, Langan, Robert A., Oberdorfer, Gustav, Ford, Alex, Gilmore, Jason, Xu, Chunfu, DiMaio, Frank, Pereira, Jose Henrique, Sankaran, Banumathi, Seelig, Georg, Zwart, Peter H., Baker, David
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497568/
https://ncbi.nlm.nih.gov/pubmed/27151862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8865
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