Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53 -independent mechanism that increases protoporphyrin IX levels and tumor cell death

Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic keratoses (AK). In the United States, PDT is only...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Anand, Sanjay, Rollakanti, Kishore R., Brankov, Nikoleta, Brash, Douglas E., Hasan, Tayyaba, Maytin, Edward V.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497500/
https://ncbi.nlm.nih.gov/pubmed/28336806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0608
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