A carregar...
Coupling of Homologous Recombination and the Checkpoint by ATR
ATR is a key regulator of cell cycle checkpoints and homologous recombination (HR). Paradoxically, ATR inhibits CDKs during checkpoint responses, but CDK activity is required for efficient HR. Here, we show that ATR promotes HR after CDK-driven DNA end resection. ATR stimulates the BRCA1-PALB2 inter...
Na minha lista:
| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5496772/ https://ncbi.nlm.nih.gov/pubmed/28089683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.007 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|