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Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-l...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chang, Jessica T, Kumsta, Caroline, Hellman, Andrew B, Adams, Linnea M, Hansen, Malene
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496740/
https://ncbi.nlm.nih.gov/pubmed/28675140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18459
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