A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

BACKGROUND: Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first event is commonly applied. There is an ongoing debate on whether multiple episodes...

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Bibliografiske detaljer
Udgivet i:BMC Med Res Methodol
Main Authors: Jahn-Eimermacher, Antje, Ingel, Katharina, Preussler, Stella, Bayes-Genis, Antoni, Binder, Harald
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496642/
https://ncbi.nlm.nih.gov/pubmed/28676086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-017-0366-9
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