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A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials
BACKGROUND: Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first event is commonly applied. There is an ongoing debate on whether multiple episodes...
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| Veröffentlicht in: | BMC Med Res Methodol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5496642/ https://ncbi.nlm.nih.gov/pubmed/28676086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-017-0366-9 |
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