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RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
RANK and CD40 activate NF-κB and MAPKs to similar levels via TRAF6. Even though overexpression of TRAF6 results in osteoclast formation, RANK but not CD40 promotes osteoclastogenesis. To understand the molecular basis for RANK-specific activity in osteoclastogenesis, we created an osteoclast formati...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549623/ https://ncbi.nlm.nih.gov/pubmed/15678102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600564 |
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