RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis

RANK and CD40 activate NF-κB and MAPKs to similar levels via TRAF6. Even though overexpression of TRAF6 results in osteoclast formation, RANK but not CD40 promotes osteoclastogenesis. To understand the molecular basis for RANK-specific activity in osteoclastogenesis, we created an osteoclast formati...

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Main Authors: Gohda, Jin, Akiyama, Toru, Koga, Takako, Takayanagi, Hiroshi, Tanaka, Sakae, Inoue, Jun-ichiro
格式: Artigo
語言:Inglês
出版: 2005
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC549623/
https://ncbi.nlm.nih.gov/pubmed/15678102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600564
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