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EGFR Inhibition in Non-Small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head

Most patients with non-small cell lung cancer who initially respond to gefitinib or erlotinib (tyrosine kinase inhibitors) ultimately develop resistance and disease relapse. What is the mechanism for this resistance?

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Détails bibliographiques
Auteurs principaux: Clark, Jennifer, Cools, Jan, Gilliland, D. Gary
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC549608/
https://ncbi.nlm.nih.gov/pubmed/15736989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020075
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