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EGFR Inhibition in Non-Small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head

Most patients with non-small cell lung cancer who initially respond to gefitinib or erlotinib (tyrosine kinase inhibitors) ultimately develop resistance and disease relapse. What is the mechanism for this resistance?

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Dettagli Bibliografici
Pubblicato in:PLoS Med
Autori principali: Clark, Jennifer, Cools, Jan, Gilliland, D. Gary
Natura: Artigo
Lingua:Inglês
Pubblicazione: PLOS 2005
Soggetti:
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549608/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15736989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1371/journal.pmed.0020075
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