High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis

Cysteinyl leukotrienes (CysLTs) are a small family of biological signaling lipids produced by active leukocytes that contribute to diverse inflammatory disease states as a consequence of their engagement with dedicated G protein-coupled receptors. Immunization of mice with a CysLT-modified hapten ca...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: King, Ashlee N., Fleming, Jonathan K., Knapik, Stephanie S., Visentin, Barbara, Wojciak, Jonathan M., Huxford, Tom
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496036/
https://ncbi.nlm.nih.gov/pubmed/28507038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M075614
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