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Biochemical and structural characterization of lysophosphatidic acid binding by a humanized monoclonal antibody

Lysophosphatidic acid (LPA) is a common product of glycerophospholipid metabolism and an important mediator of signal transduction. Aberrantly high LPA concentrations accompany multiple disease states. One potential approach for treatment of these diseases, therefore, is the therapeutic application...

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Main Authors: Fleming, Jonathan K., Wojciak, Jonathan M., Campbell, Mary-Ann, Huxford, Tom
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075315/
https://ncbi.nlm.nih.gov/pubmed/21392506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.02.061
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