Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter

Chronic stress and elevated glucocorticoid hormone are associated with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1). Human/rat CLDN1 promoters contain glucocorticoid response elements (GREs) and adjacent transcription repressor HES1 binding N-boxes. Notch signaling...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Zheng, Gen, Victor Fon, Gordon, Meixner, Walter, Creekmore, Amy, Zong, Ye, K. Dame, Michael, Colacino, Justin, Dedhia, Priya H., Hong, Shuangsong, Wiley, John W.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495803/
https://ncbi.nlm.nih.gov/pubmed/28674421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04755-w
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars