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Quantitative Protein Topography Measurements by High Resolution Hydroxyl Radical Protein Footprinting Enable Accurate Molecular Model Selection

We report an integrated workflow that allows mass spectrometry-based high-resolution hydroxyl radical protein footprinting (HR-HRPF) measurements to accurately measure the absolute average solvent accessible surface area (<SASA>) of amino acid side chains. This approach is based on application...

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Foilsithe in:Sci Rep
Main Authors: Xie, Boer, Sood, Amika, Woods, Robert J., Sharp, Joshua S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495787/
https://ncbi.nlm.nih.gov/pubmed/28674401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04689-3
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