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Target-dependent on/off switch increases ribozyme fidelity

Ribozymes, RNA molecules that catalyze the cleavage of RNA substrates, provide an interesting alternative to the RNA interference (RNAi) approach to gene inactivation, especially given the fact that RNAi seems to trigger an immunological response. Unfortunately, the limited substrate specificity of...

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Bibliografiske detaljer
Main Authors: Bergeron, Lucien Junior, Perreault, Jean-Pierre
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC549572/
https://ncbi.nlm.nih.gov/pubmed/15731344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki278
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