Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch

Ubiquitin (Ub) is an important signaling protein. Recent studies have shown that Ub can be enzymatically phosphorylated at S65, and that the resulting pUb exhibits two conformational states—a relaxed state and a retracted state. However, crystallization efforts have yielded only the structure for th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Dong, Xu, Gong, Zhou, Lu, Yun-Bi, Liu, Kan, Qin, Ling-Yun, Ran, Meng-Lin, Zhang, Chang-Li, Liu, Zhu, Zhang, Wei-Ping, Tang, Chun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495273/
https://ncbi.nlm.nih.gov/pubmed/28611216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705718114
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