Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch

Ubiquitin (Ub) is an important signaling protein. Recent studies have shown that Ub can be enzymatically phosphorylated at S65, and that the resulting pUb exhibits two conformational states—a relaxed state and a retracted state. However, crystallization efforts have yielded only the structure for th...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Dong, Xu, Gong, Zhou, Lu, Yun-Bi, Liu, Kan, Qin, Ling-Yun, Ran, Meng-Lin, Zhang, Chang-Li, Liu, Zhu, Zhang, Wei-Ping, Tang, Chun
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495273/
https://ncbi.nlm.nih.gov/pubmed/28611216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705718114
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