Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fei, Teng, Chen, Yiwen, Xiao, Tengfei, Li, Wei, Cato, Laura, Zhang, Peng, Cotter, Maura B., Bowden, Michaela, Lis, Rosina T., Zhao, Shuang G., Wu, Qiu, Feng, Felix Y., Loda, Massimo, He, Housheng Hansen, Liu, X. Shirley, Brown, Myles
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495225/
https://ncbi.nlm.nih.gov/pubmed/28611215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617467114
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