m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

Understanding the biologic role of N(6)-methyladenosine (m(6)A) RNA modifications in mRNA requires an understanding of when and where in the life of a pre-mRNA transcript the modifications are made. We found that HeLa cell chromatin-associated nascent pre-mRNA (CA-RNA) contains many unspliced intron...

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Vydáno v:Genes Dev
Hlavní autoři: Ke, Shengdong, Pandya-Jones, Amy, Saito, Yuhki, Fak, John J., Vågbø, Cathrine Broberg, Geula, Shay, Hanna, Jacob H., Black, Douglas L., Darnell, James E., Darnell, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495127/
https://ncbi.nlm.nih.gov/pubmed/28637692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.301036.117
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