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Early onset of puberty and early ovarian failure in CYP7B1 knockout mice
CYP7B1 is the enzyme responsible for hydroxylation and termination of the estrogenic actions of the androgen metabolite, 5α-androstane-3β, 17β-diol (3βAdiol). 3βAdiol is estrogenic in ERα or ERβ positive cells only if they do not express CYP7B1. In this study we show that female CYP7B1(–/–) mice exp...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549492/ https://ncbi.nlm.nih.gov/pubmed/15710898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500198102 |
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