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Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice

Male mice with inactivated liver X receptor (LXR) β suffer from adult-onset motor neuron degeneration. By 7 months of age, motor coordination is impaired, and this condition is associated with lipid accumulation and loss of motor neurons in the spinal cord, together with axonal atrophy and astroglio...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Andersson, Sandra, Gustafsson, Nina, Warner, Margaret, Gustafsson, Jan-Åke
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2005
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553330/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15738425/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500634102
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