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A critical role of helix 3–helix 5 interaction in steroid hormone receptor function
The ligand-binding domains of steroid hormone receptors possess a conserved structure with 12 α-helices surrounding a central hydrophobic core. On agonist binding, a repositioned helix 12 forms a pocket with helix 3 (H3) and helix 5 (H5), where transcriptional coactivators bind. The precise molecula...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549476/ https://ncbi.nlm.nih.gov/pubmed/15710879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409663102 |
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