Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions

Gangliosides, which are sialylated glycosphingolipids, are the major class of glycoconjugates on neurons and carry the majority of the sialic acid within the central nervous system (CNS). To determine the role of ganglioside synthesis within the CNS, mice carrying null mutations in two critical gang...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Yamashita, Tadashi, Wu, Yun-Ping, Sandhoff, Roger, Werth, Norbert, Mizukami, Hiroki, Ellis, Jessica M., Dupree, Jeffrey L., Geyer, Rudolf, Sandhoff, Konrad, Proia, Richard L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549464/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15710896/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0407785102
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