Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions

Gangliosides, which are sialylated glycosphingolipids, are the major class of glycoconjugates on neurons and carry the majority of the sialic acid within the central nervous system (CNS). To determine the role of ganglioside synthesis within the CNS, mice carrying null mutations in two critical gang...

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Detalhes bibliográficos
Main Authors: Yamashita, Tadashi, Wu, Yun-Ping, Sandhoff, Roger, Werth, Norbert, Mizukami, Hiroki, Ellis, Jessica M., Dupree, Jeffrey L., Geyer, Rudolf, Sandhoff, Konrad, Proia, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549464/
https://ncbi.nlm.nih.gov/pubmed/15710896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407785102
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