TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. In the brain, TREM2 is predominantly expressed in microglia. Several disea...

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Publicado en:EMBO Rep
Autores principales: Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494532/
https://ncbi.nlm.nih.gov/pubmed/28483841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201743922
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