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β-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids
Most μ-opioid receptor agonists recruit β-arrestin2, with some exceptions such as morphine. Surprisingly, however, the acute analgesic effect of morphine is enhanced in the absence of β-arrestin2. To resolve this paradox, we examined the effects of morphine and fentanyl in acute brain slices of the...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549451/ https://ncbi.nlm.nih.gov/pubmed/15718284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406632102 |
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