Human lactoferrin efficiently targeted into caprine beta-lactoglobulin locus with transcription activator-like effector nucleases

OBJECTIVE: To create genetically modified goat as a biopharming source of recombinant human lacotoferrin (hLF) with transcription activator-like effector nucleases. METHODS: TALENs and targeting vector were transferred into cultured fibroblasts to insert hLF cDNA in the goat beta-lactoglobulin (BLG)...

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Publicado no:Asian-Australas J Anim Sci
Main Authors: Yuan, Yu-Guo, Song, Shao-Zheng, Zhu, Meng-Ming, He, Zheng-Yi, Lu, Rui, Zhang, Ting, Mi, Fei, Wang, Jin-Yu, Cheng, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494492/
https://ncbi.nlm.nih.gov/pubmed/28002927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5713/ajas.16.0697
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