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The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

The recent elucidation of the structure of the carboxyl-terminal region of the hyperpolarization-activated cyclic nucleotide-modulated (HCN2) channel has prompted us to investigate a curious feature of this structure in HCN2 channels and in the related CNGA1 cyclic nucleotide-gated (CNG) channels. T...

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Bibliographic Details
Main Authors: Johnson, J. P., Zagotta, William N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549449/
https://ncbi.nlm.nih.gov/pubmed/15710893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408323102
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