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The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

The recent elucidation of the structure of the carboxyl-terminal region of the hyperpolarization-activated cyclic nucleotide-modulated (HCN2) channel has prompted us to investigate a curious feature of this structure in HCN2 channels and in the related CNGA1 cyclic nucleotide-gated (CNG) channels. T...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Johnson, J. P., Zagotta, William N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549449/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15710893/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408323102
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