E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

Optimal regulation of the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is essential for controlling bacterial infections and inflammatory disorders. Chronic NOD2 stimulation induces non-responsiveness to restimulation, termed NOD2-induced tolerance. Al...

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Udgivet i:Nat Commun
Main Authors: Bist, Pradeep, Cheong, Wan Shoo, Ng, Aylwin, Dikshit, Neha, Kim, Bae-Hoon, Pulloor, Niyas Kudukkil, Khameneh, Hanif Javanmard, Hedl, Matija, Shenoy, Avinash R., Balamuralidhar, Vanniarajan, Malik, Najib Bin Abdul, Hong, Michelle, Neutzner, Albert, Chin, Keh-Chuang, Kobayashi, Koichi S., Bertoletti, Antonio, Mortellaro, Alessandra, Abraham, Clara, MacMicking, John D., Xavier, Ramnik J., Sukumaran, Bindu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493756/
https://ncbi.nlm.nih.gov/pubmed/28656966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15865
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