0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

DNA-damaging agents have been used in cancer chemotherapy for a long history. Unfortunately, chemotherapeutic treatment strategies against hepatocellular carcinoma (HCC) are still ineffective. We screened a novel DNA-damaging compound, designated as 0404, by using time-dependent cellular response pr...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Xia, Caixia, Shui, Liyan, Lou, Guohua, Ye, Bingjue, Zhu, Wei, Wang, Jing, Wu, Shanshan, Xu, Xiao, Mao, Long, Xu, Wanhong, Chen, Zhi, Liu, Yanning, Zheng, Min
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493669/
https://ncbi.nlm.nih.gov/pubmed/28667294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04487-x
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