Emergence and Evolution of Enfuvirtide Resistance following Long-Term Therapy Involves Heptad Repeat 2 Mutations within gp41

Eitemau Tebyg

• Impact of Human Immunodeficiency Virus Type 1 gp41 Amino Acid Substitutions Selected during Enfuvirtide Treatment on gp41 Binding and Antiviral Potency of Enfuvirtide In Vitro
  gan: Mink, M., et al.
  Cyhoeddwyd: (2005)
• Oligomerization of the hydrophobic heptad repeat of gp41.
  gan: Bernstein, H B, et al.
  Cyhoeddwyd: (1995)
• Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor
  gan: Derdeyn, Cynthia A., et al.
  Cyhoeddwyd: (2001)
• Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket
  gan: Yu, Xiaowen, et al.
  Cyhoeddwyd: (2012)
• Selection with a Peptide Fusion Inhibitor Corresponding to the First Heptad Repeat of HIV-1 gp41 Identifies Two Genetic Pathways Conferring Cross-Resistance to Peptide Fusion Inhibitors Corresponding to the First and Second Heptad Repeats (HR1 and HR2) of gp41
  gan: Wang, Wei, et al.
  Cyhoeddwyd: (2011)