Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML

Lamins form a scaffold lining the nucleus that binds chromatin and contributes to spatial genome organization; however, due to the many other functions of lamins, studies knocking out or altering the lamin polymer cannot clearly distinguish between direct and indirect effects. To overcome this obsta...

Full description

Saved in:

Bibliographic Details
Published in:	Cells
Main Authors:	Dixon, Charles R., Platani, Melpomeni, Makarov, Alexandr A., Schirmer, Eric C.
Format:	Artigo
Language:	Inglês
Published:	MDPI 2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5492013/ https://ncbi.nlm.nih.gov/pubmed/28346356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells6020009
Tags:	Add Tag No Tags, Be the first to tag this record!

Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML

Similar Items