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4-PBA and metformin decrease sensitivity to PTZ-induced seizures in a malin knockout model of Lafora disease
Lafora disease (LD) is a rare adolescent-onset progressive myoclonic epilepsy caused by loss-of-function mutations either in the EPM2A gene encoding laforin or in the EPM2B gene encoding malin. Mouse models with deletion in the Epm2a or Epm2b gene display intracellular aggregates of polyglucosans (L...
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| Publicado en: | Neuroreport |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491969/ https://ncbi.nlm.nih.gov/pubmed/28181916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000000751 |
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