Cellular uptake and anti-tumor activity of gemcitabine conjugated with new amphiphilic cell penetrating peptides

Gemcitabine (Gem) is used as a single agent or in combination with other anticancer agents to treat many types of solid tumors. However, it has many limitations such as a short plasma half-life, dose-limiting toxicities and drug resistance. Cell-penetrating peptides (CPPs) are short peptides which m...

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Detalhes bibliográficos
Publicado no:EXCLI J
Main Authors: Zakeri-Milani, Parvin, Mussa Farkhani, Samad, Shirani, Ali, Mohammadi, Samaneh, Shahbazi Mojarrad, Javid, Akbari, Jafar, Valizadeh, Hadi
Formato: Artigo
Idioma:Inglês
Publicado em: Leibniz Research Centre for Working Environment and Human Factors 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491906/
https://ncbi.nlm.nih.gov/pubmed/28694765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2017-249
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