Angiotensin II activates Ca(V)1.2 Ca(2+) channels through β‐arrestin2 and casein kinase 2 in mouse immature cardiomyocytes

KEY POINTS: Angiotensin II (AngII) is crucial in cardiovascular regulation in perinatal mammalians. Here we show that AngII increases twitch Ca(2+) transients of mouse immature but not mature cardiomyocytes by robustly activating Ca(V)1.2 L‐type Ca(2+) channels through a novel signalling pathway inv...

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Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Kashihara, Toshihide, Nakada, Tsutomu, Kojima, Katsuhiko, Takeshita, Toshikazu, Yamada, Mitsuhiko
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Cardiovascular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491886/
https://ncbi.nlm.nih.gov/pubmed/28295363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273883
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