The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity

The degeneration of dopaminergic neurons during Parkinson’s disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in seve...

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Bibliografische gegevens
Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: Aufschnaiter, Andreas, Habernig, Lukas, Kohler, Verena, Diessl, Jutta, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Keller, Walter, Büttner, Sabrina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2017
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491553/
https://ncbi.nlm.nih.gov/pubmed/28713240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00207
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