Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

BACKGROUND: Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogen...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Burlion, Aude, Brunel, Simon, Petit, Nicolas Y., Olive, Daniel, Marodon, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491549/
https://ncbi.nlm.nih.gov/pubmed/28713380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00756
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