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Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE
GLUT1 facilitates the down-gradient translocation of D-glucose across cell membrane in mammals. XylE, an Escherichia coli homolog of GLUT1, utilizes proton gradient as an energy source to drive uphill D-xylose transport. Previous studies of XylE and GLUT1 suggest that the variation between an acidic...
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| Veröffentlicht in: | PLoS Comput Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491310/ https://ncbi.nlm.nih.gov/pubmed/28617850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005603 |
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