Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury

Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis. In this study, we tested whether APA expression changes in response to progressive nephron loss or whether APA exerts a protective...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Velez, Juan Carlos Q., Arif, Ehtesham, Rodgers, Jessalyn, Hicks, Megan P., Arthur, John M., Nihalani, Deepak, Bruner, Evelyn T., Budisavljevic, Milos N., Atkinson, Carl, Fitzgibbon, Wayne R., Janech, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491295/
https://ncbi.nlm.nih.gov/pubmed/28202497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016111166
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