Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity

Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remain largely unknown. Here, we have presented evidence supporting the essential function of...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhang, Deqiang, Tong, Xin, VanDommelen, Kyle, Gupta, Neil, Stamper, Kenneth, Brady, Graham F., Meng, Zhuoxian, Lin, Jiandie, Rui, Liangyou, Omary, M. Bishr, Yin, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490767/
https://ncbi.nlm.nih.gov/pubmed/28628040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89934
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