Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

Mutations in WNT1 cause osteogenesis imperfecta (OI) and early-onset osteoporosis, identifying it as a key Wnt ligand in human bone homeostasis. However, how and where WNT1 acts in bone are unclear. To address this mechanism, we generated late-osteoblast-specific and osteocyte-specific WNT1 loss- an...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Joeng, Kyu Sang, Lee, Yi-Chien, Lim, Joohyun, Chen, Yuqing, Jiang, Ming-Ming, Munivez, Elda, Ambrose, Catherine, Lee, Brendan H.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490765/
https://ncbi.nlm.nih.gov/pubmed/28628032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92617
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