Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of cases of severe hypertension worldwide. Either of 2 somatic mutations in the potassium channel KCNJ5 (G151R and L168R, hereaft...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Scholl, Ute I., Abriola, Laura, Zhang, Chengbiao, Reimer, Esther N., Plummer, Mark, Kazmierczak, Barbara I., Zhang, Junhui, Hoyer, Denton, Merkel, Jane S., Wang, Wenhui, Lifton, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490757/
https://ncbi.nlm.nih.gov/pubmed/28604387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91733
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