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Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins

A rapid and selective ligand-directed chemical reaction was developed for the acylation of proteins in living cells on the basis of ligand-directed chemistry. By fine tuning the reactivity and stability of the phenyl ester derivatives, we successfully identified ortho-dibromophenyl benzoate as the o...

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Pubblicato in:Chem Sci
Autori principali: Takaoka, Yousuke, Nishikawa, Yuki, Hashimoto, Yuki, Sasaki, Kenta, Hamachi, Itaru
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490417/
https://ncbi.nlm.nih.gov/pubmed/28706692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00190k
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