HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates

OBJECTIVES: This study sought to test the hypothesis that hyperpolarization-activated cyclic nucleotide–gated (HCN)–based biological pacing might be improved significantly by hyperpolarizing the action potential (AP) threshold via coexpression of the skeletal muscle sodium channel 1 (SkM1). BACKGROU...

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Vydáno v:J Am Coll Cardiol
Hlavní autoři: Boink, Gerard J. J., Duan, Lian, Nearing, Bruce D., Shlapakova, Iryna N., Sosunov, Eugene A., Anyukhovsky, Evgeny P., Bobkov, Eugene, Kryukova, Yelena, Ozgen, Nazira, Danilo, Peter, Cohen, Ira S., Verrier, Richard L., Robinson, Richard B., Rosen, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490253/
https://ncbi.nlm.nih.gov/pubmed/23395072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2012.12.031
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