Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

T cells expressing a CD19-specific chimeric antigen receptor (CAR19) are demonstrating remarkable efficacy in hematologic malignancies. Treatment is often associated with life-threatening cytokine release syndrome (CRS) which can be effectively treated with cytokine blockade using the antibodies, Si...

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Pubblicato in:J Immunol Methods
Autori principali: Chen, Fang, Teachey, David T., Pequignot, Edward, Frey, Noelle, Porter, David, Maude, Shannon L., Grupp, Stephan A., June, Carl H., Melenhorst, Jan J., Lacey, Simon F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490247/
https://ncbi.nlm.nih.gov/pubmed/27049586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2016.03.005
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